Human Nectin-1 / PVRL1 / CD111 Protein, Fc Tag from ACROBiosystems

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Human Nectin-1 / PVRL1 / CD111 Protein, Fc Tag

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Description

Poliovirus receptor-related protein 1 (PVRL1) is also known as Herpes virus entry mediator C (HveC), Herpesvirus Ig-like receptor (HIgR), Nectin-1, CD antigen CD111, PVRL1 / Nectin-1 / CD111 belongs to the nectin family.

PVRL1 / Nectin-1 is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail.

The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).

PVRL1 is adhesion molecule found in a wide range of tissues.

PVRL1 / Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers.

Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4